General

Drug use and damages in pregnancy

Drug use and damages in pregnancy

During pregnancy, expectant mothers should only use the medications recommended by their physician. Memorial Hospital Genetic Laboratory Specialist Genetics and Pharmacology Specialist Gülay Özgön, Olmadan Do not use constipation, sleep medications, tranquilizers, painkillers and aspirin taken from the pharmacy without medical advice. It is best not to take medication unless it is very compulsory. ”

Do drugs during pregnancy lead to disasters?

Advances in clinical pharmacology have led to the fear that drug use during pregnancy can lead to catastrophes and unforeseeable consequences. This fear naturally limited experimental studies during pregnancy and caused the information obtained today to be limited only to the experiences. For example; hypertension, epilepsy, asthma and bacterial infection, such as drug treatment is mandatory in which cases which drug should be administered at which dose was interpreted differently.

The most commonly used drugs during pregnancy:

Investigations and researches have shown that antibiotics take the first place in drug use in pregnant women. Next rankings; analgesics, tranquilizers and drugs that prevent nausea and vomiting.

Is the period of use important?

When talking about the risks of taking medication during pregnancy, it is necessary to consider the period of pregnancy. Because drug effects are different according to pregnancy periods. For example, while the first 3 months of pregnancy - in the period when the organs of the baby occur - is a period in which anomalies occur quite heavily, the effects of the medications taken in later periods are not so severe and affect the growth and development negatively.

Teratogenic factors:

Even in developed countries, 2 percent of all births have anomalies. Genetic reasons, infections in the uterus of the baby, the mother's diabetes, chronic diseases such as diabetes, epilepsy and the mothers; In addition to alcohol, other drug addiction or exposure to radiation, some medications can also lead to disabled babies. Previously disabled baby birth or recurrent miscarriages in the family are also factors that increase the risk. These families should be monitored more carefully during pregnancy.

How does the drug that the mother takes?

The medication that the mother takes is passed through the umbilical cord (placenta) which is the feeding tool of the baby. The drugs or nutrients that the mother takes through the placenta show the negative effects on the tissues of the baby that they will show their effects. Studies have shown that each drug does not cross the placenta equally. The reasons for this are; the fat solubility of the drug, the mother's ability to bind the drug to blood proteins and the rate of metabolization of the drug by the mother and placenta were determined. As a result, although the percentage of drugs crossing the placenta barrier is unknown, the amount of drug delivered to the infant is never clearly known due to individual differences in society.

The principles used in the assessment of the baby's exposure to the drug:

● The susceptibility of the baby to the drug is genetically determined.
● There is no special placental transition.
● The time of exposure to the drug is very important.
● The degree of infant exposure is usually dose-dependent.
● While the medications used may be beneficial to the mother, they may be harmful to the fetus and may even have fatal consequences.

Infants to be affected by the drug can cause some problems in the elderly!

In recent years; showed that the cause of psychomotor retardation in children aged school age may be late effects of drug effects.